Richard Bucala MD, PhD

Professor of Medicine (Rheumatology), of Epidemiology (Microbial Diseases) and of Pathology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Medicine, Pharmacology, and Physiology

Yale Medical Group

Office of Student ResearchInfectious DiseasesStem Cell Center, YaleCancer ImmunologyHTI | School of Public Health: Parasitology ProgramSkin Diseases Research Center, Yale | Pathology | Internal Medicine: Rheumatology; Diabetes Research Center

Research Interests

Mechanisms by which host immunity converts from a protective response to one producing disease and tissue pathology; Emergence of steroid resistance; Biochemical, biological, and genetic characterization of the MIF cytokine family; MIF's role in malaria and global infectious diseases; Pharmacologic immuniomodulation of the MIF pathway; Role of fibrocytes in different systemic fibroses more...


  • B.S., Yale University, 1979
  • M.S., Yale University, 1979
  • Ph.D., Rockefeller University, 1985
  • M.D., Cornell College, 1986

Selected Publications

  • Sreih A, Ezzeddine R, Leng L, Lachance A, Yu G, Mizue Y, Subrahmanyan L, Pons-Estel BA, Abelson AK, Gunnarsson I, Svenungsson E, Cavett J, Glenn S, Zhang L, Montgomery R, Perl A, Salmon J, Alarcón-Riquelme ME, Harley JB, Bucala R. 2011. Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus. Arthritis Rheum. 63:3942-3951. PMCID: PMC3228269
  • Leng L, Chen L, Fan J, Greven D, Arjona A, Du X, Austin D, Kashgarian M, Yin Z, Huang XR, Lan HY, Lolis E, Nikolic-Paterson D, Bucala R. 2011. A small-molecule MIF antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice. J Immunol. 186:527-538. PMCID: PMC3124407
  • Jorgensen WL, Gandavadi S, Du X, Hare AA, Trofimov A, Leng L, Bucala R. 2010. Receptor agonists of macrophage migration inhibitory factor. Bioorg Med Chem Lett. 20:7033-7036. PMCID: PMC2989669



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