Narendra Wajapeyee, PhD

Assistant Professor of Pathology

Departments & Organizations

Pathology: ExPath | Pathology Research | Wajapeyee Lab

Cancer Center: Signal Transduction

Faculty Research

Liver Center

Office of Student Research

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Medicine, Pharmacology, and Physiology: Cancer Biology and Therapeutics; Genetics, Genomics and Proteomics; Human Disease Pathology, Physiology and Intervention

Office of Cooperative Research

Biography

Cancer is a complex disease and typically involves multiple gene-specific and global genetic and epigenetic changes in human genome. The major classes of genes that have been causally linked to the process of tumorigenesis is tumor suppressors, which act as “brakes”, and oncogenes, which function as “accelerators” and typically promote cancer. Recently, non-coding RNAs such as miRNAs and long non-coding RNAs are also linked to cancer, wherein they can either promote or inhibit cancer cell growth. The focus of our lab is to understand the mechanisms of genetic and epigenetic regulation of cancer initiation and progression and translating this understanding for early detection and treatment of human cancers. We use melanoma, pancreatic cancer, lung cancer, hepatocellular carcinoma and hematological malignancies as model systems to study mechanism of tumor initiation and progression.

Specialized Terms: Genetic and epigenetic mechanisms of cancer initiation and progression

Education & Training

PhD Indian Institute of Science, India (2005)

Honors & Recognition

  • Research Scholar Grant, American Cancer Society, 2016 (2015)

  • Yale Cancer Center Translational Cancer Research Excellence PrizeYale Cancer Center (2014)

  • IASLC Young Investigator AwardInternational Association for the Study of Lung Cancer (2013)

  • Young Investigator AwardMelanoma Research Alliance (2013)

  • Kimmel Scholar for Translational Cancer ResearchSidney Kimmel Foundation for Cancer Research (2012)

  • Hollis Brownstein Award for Leukemia ResearchLeukemia Research Foundation (2011)

  • AACR Centennial Cancer Research Award for Childhood Cancer ResearchAmerican Association for Cancer Research (2010)

Edit this profile