Marie E Egan MD

Professor of Pediatrics (Respiratory) and of Cellular and Molecular Physiology; Director, Cystic Fibrosis Center

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Medicine, Pharmacology, and Physiology

Yale Medical Group

LCME Education Subcommittee

Office of Student ResearchStem Cells and Tissue RepairCellular & Molecular Physiology: Membrane Proteins - Ion Channels; Membrane Protein Sorting and Trafficking; Epithelial Transport of Ions and Solutes; Physiology of Human Disease; Physiology and Integrative Medical Biology Track; Graduate Program in Cellular and Molecular PhysiologyPediatrics: Pediatric Respiratory Medicine: Pediatric Asthma Program, Cystic Fibrosis Program, Pediatric; Pediatric Specialty Center; Pediatric Faculty Development Group

Research Interests

Cystic fibrosis clinical studies; Cystic fibrosis basic science research (ion transport, Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) function); Cystic fibrosis translational research studies (strategies to bypass the basic defect) more...


  • M.D., Mount Sinai School of Medicine, 1986

Selected Publications

  • Bruscia E., PX. Zhang, A. Satoh, C. Caputo, R. Medzhitov, A. Shenoy, M.E. Egan D.S. Krause. Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis, Journal of Immunology. 186: 6990-6998, 2011. (D.S.K. and M.E.E. contributed equally to this project and each should be considered as senior author.)
  • Bruscia E, Zhang P-X, Ferreira E, Caputo C, Emerson J, Krause D, Egan ME. Macrophages directly contribute to the hyper pro-inflammatory response in Cftr -/- mice. Am J Resp Cell & Mol Biol, 40:295-304, 2009.
  • Egan ME, Pearson M, Weiner S, Rubin D, Lukcas G, Du K, Rajendran V, Glockner-Pagel J, Canny S, Caplan MC. Curcumin, a major constituent of the spice tumeric, corrects cystic fibrosis defects. Science, 304:600-2, 2004.



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