Gerald S Shadel PhD
Professor of Pathology and of Genetics; Director, Pathology Research
Departments & Organizations
Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology
Pathology: Pathology Research | Shadel Lab
Genetics
Research Interests
Mitochondria; Mitochondrial Genetics and Biogenesis; Mitochondrial Dysfunction in Human Disease and Aging; Mechanisms of mtDNA Transcription and Mitochondrial Translation; Signaling Pathways that Sense and Control Mitochondrial Function; Cancer; Immune System Signaling more...
Education
- B.S., University of Nevada, Las Vegas, 1986
- Ph.D., Texas A & M University, 1991
Selected Publications
- Raimundo N, Song L, Shutt TE, Mckay SE, Cotney J, Guan M-X, Gilliland TC, Hohuan, D, Santos-Sacchi J & Shadel GS. (2012) Mitochondrial Stress engages E2F1 apoptotic signaling to cause deafness. Cell, 148:716-726.
- Woo DK, Green PD, Santos JH, D’Souza AD, Walther Z, Martin, WD, Christian BE, Chandel NS & Shadel GS. (2012) Mitochondrial Genome Instability and ROS enhance tumorigenesis in APCMin/+ mice. Am J Pathology. 180:24-31.
- D’Souza AD, Parish IA, Krause DS, Kaech SM, & Shadel GS. (2012) Reducing Mitochondrial ROS Improves disease-related pathology in a mouse model of Ataxia-telangiectasia. Molecular Therapy, September 25.
