Michael Harris Nathanson MD, PhD

Gladys Phillips Crofoot Professor of Medicine (Digestive Diseases) and Professor of Cell Biology; Section Chief, Digestive Diseases; Director, Yale Liver Center; Director, Center for Cell and Molecular Imaging

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

Yale Medical Group

Transplantation Center, Yale-New Haven

Cell Biology: Membrane Traffic | Center for Cellular and Molecular Imaging

Internal Medicine: Digestive Diseases: Hepatology | Gastrointestinal Procedure Center

Research Interests

Mechanisms and effects of calcium signals in polarized epithelia; Effect of spatial organization of calcium signals on organ function regulation; Factors that organize Ca2+ waves in hepatocytes; Organization and effects of Ca2+ waves in cholangiocytes; Mechanisms and effects of Ca2+ signals in the nucleus more...


  • B.S., University of California, Berkeley, 1976
  • M.S., Massachusetts Institute of Technology, 1977
  • Ph.D., Case Western Reserve Univ, 1983
  • M.D., Case Western Reserve Univ, 1985

Selected Publications

  • Mennone, A., and Nathanson, M.H.: Needle-based confocal laser endomicroscopy to assess liver histology in vivo. Gastrointestinal Endoscopy, in press.
  • Cruz, L.N., Guerra, M.T., Kruglov, E.A., Mennone, A., Garcia, C.R.S., Chen, J., and Nathanson, M.H.: Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver. Hepatology 52:327-337, 2010.
  • Rodrigues, M.A., Gomes, D.A., Leite, M.F., and Nathanson, M.H.: Insulin induces calcium signals in the nucleus of rat hepatocytes. Hepatology 48: 1621-1631, 2008.



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