Daniel C. DiMaio MD, PhD

Waldemar Von Zedtwitz Professor of Genetics and Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology; Scientific Director, Yale Cancer Center; Deputy Director, Yale Cancer Center

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Microbiology | Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural BiologyCancer Center, Yale: Molecular VirologyCenter for RNA Science and Medicine, YaleHPV | Molecular Biophysics and BiochemistryTherapeutic Radiology/Radiation Oncology: Radiobiology | GeneticsMolecular Virology

Research Interests

Molecular Biology of Tumor Viruses; Mechanisms of Viral Carcinogenesis; Molecular Basis of Cell Growth Regulation and Senescence; Manipulating Cells and Viruses with Artificial Transmembrane Proteins; Oncogenes; Senescence; Signal Transduction; Trans-membrane Proteins; Tumor Suppressor Genes; Virology; Virus more...


  • M.D., Johns Hopkins University, 1978
  • Ph.D., Johns Hopkins University, 1981

Selected Publications

  • Petti, L.M., Talbert-Slagle, K., Hochstrasser, M., and DiMaio, D. (2013) A single amino acid substitution converts a transmembrane protein activator of the platelet-derived growth factor ß receptor into an inhibitor. J. Biol. Chem. (In press) PMID:23908351
  • Edwards, A.P.B., Xie, Y., Ely-Bowers, L., and DiMaio, D. (2013) Compensatory mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor ß receptor reveal a complex direct transmembrane interaction. J. Virol. 87: (In press)
  • Iijima, N., Goodwin, E.C., DiMaio, D., and Iwasaki, A. (2013) High-risk human papillomavirus E6 inhibits monocyte differentiation to Langerhans cells. Virology, Jul 17. doi:pii: S0042-6822(13)00388-7. 10.1016/j.virol.2013.06.020. [Epub ahead of print] PMID: 23871219.



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