Diane McMahon-Pratt, PhD

Professor of Epidemiology (Microbial Diseases)

Departments & Organizations

Infectious Diseases

Office of Student Research

School of Public Health: Epidemiology of Microbial Diseases: Vaccine Group; Vector-borne | Global Health Concentration | Parasitology Program

Skin Diseases Research Center, Yale

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Microbiology

Biography

The research in Professor McMahon-Pratt's laboratory is concerned with the parasitic protozoan, Leishmania, which causes a spectrum of diseases known as leishmaniasis. The laboratory is interested in understanding the immune effector mechanisms in the mammalian host that are involved in the control of infection and/or pathogenesis, with the aim to developing a vaccine against leishmaniasis. The laboratory has defined target vaccine candidate molecules and is collaborating with the University of Iowa and Cambridge University in a project directed toward the development of a multi-subunit vaccine. In addition, we are collaborating with Dr. Tarek Fahmy (L Yale Bioengineering) in the development of nanoparticle therapeutic treatment delivery system for leishmaniasis. In other studies, the laboratory also collaborates Drs. Al Bothwell and Eddie Chae (Immunobiology) investigating the role of DKK-1 in the regulation of the innate and T cell responses to Leishmania infection. We have long-term collaboration with scientists in Colombia. Currently, Professor McMahon-Pratt is director of NIAID R01 and Fogarty (NIH)-sponsored Programs with Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM) in Colombia. These program are focused on understanding the pathology of leishmaniasis caused by Leishmania (Viannia), which predominates in South America, with the objective of designing immunological approaches for treatment and control.

Education & Training

PhD Harvard University (1978)
BS University of Southern California (1969)
Post-Doctoral Fellow Harvard Medical School

Honors & Recognition

  • Councilor, American Society for Tropical Medicine and Hygiene (1993)

  • Burroughs-Welccome Lecturer, NIH Laboratory of Parasitic Diseasea (1994)

  • Organizer, Gordon Conference on Biological Aspects of Parasitism (1991), (1993)

  • Bailey K. Ashford Medal, American Society of Tropical Medicine and Hygiene (1993)

Professional Service

  • Member, Program Committee Member, Program Committee, American Society of Tropical Medicine and Hygiene (2001)

  • WorldLeish3 –Italy, April, 2005: Organizing Committee (2004 - 2005)

  • Co-organizer (with Drs. J. Blackwell (Cambridge University), Paul Kaye (University of York) and Mary Wilson (University of Iowa)). International Conference on post-genomic research strategies for the development of vaccines and drugs against leishmaniasis. Cotswalds, England. September, 2007. Co-Organizer, International Conference on post-genomic research strategies for the development of vaccines and drugs against leishmaniasis. (2006 - 2007)

  • Organizer, W.H.O. Workshop, December, 1992. Pan American Health Organization. Washington, D.C. World Health Organization and Pan American Health Organization, Workshop Organizer. Washington, D.C (1991 - 1992)

  • Organizer, W.H.O. Workshop, December 1993, Identification and diagnosis of Leishmania species. Cali, Colombia. (1992 - 1993)

  • WHO/T.D.R. Review of Leishmaniasis Program (2004)

  • Yale University School of Medicine: Senior Faculty Allotment Committee (2001 - 2004)

  • Provost’s Appointments and Promotions Committee of EPH

  • International Health Committee (Downs Fellowship) (1988 - 1994)

  • Appointments and Promotions Committee, Yale University School of Medicine (1998 - 2000)

  • International Health Committee (2009 - 2011)

  • Served as a reviewer for grant applications to the National Science Foundation, Canadian Research Foundation, Veterans Administration and World Health Organization and US Army Research, Wellcome Trust (England) (1990)

  • Review Panel, Howard Hughes, International Infectious Disease Program (2000)

  • NIH - Microbiology and Infectious Disease Research Study Section Member (2001 - 2004)

  • Study Section member - Tropical Medicine and Parasitology NIH Study Section member - Tropical Medicine and Parasitology (1988 - 1992)

  • Editorial Board, Memorias Oswaldo Cruz (1993 - 2004)

  • Editorial Board, PLoS Neglected Tropical Diseases (2008)

  • Editorial Board Editorial Board, American Journal of Tropical Medicine and Hygiene (1999)

International Activity

  • Improved Treatment of American Cutaneous Leishmaniasis by Immunomodulation Colombia (2011 - 2015)

    This application is a collaborative project with Dr. N. Saravia at CIDEIM (Colombia) which is focused on the development of immunomodulatory therapy for cutaneous leishmaniasis caused by Leishmania (Viannia). The murine model of chronic disease is being used to interrogate new approaches for...

  • Vector/Host-Parasite Interface of Leishmaniasis in Colombia Cali, Colombia (2011)

    The goal of the training grant is to build research capacity to identify strategies and devise means to interrupt the cycle of transmission and pathogenesis of leishmaniasis through intervention of the invertebrate and vertebrate host pathogen interactions. To achieve this goal, the training...

  • Immunology and epidemiology of leishmaniasis Colombia (1985)

Edit this profile

Contact Info

Diane McMahon-Pratt, PhD
Office Location
Laboratory of Epidemiology and Public Health
60 College Street, Ste 811

New Haven, CT 06510
Mailing Address
Yale School of Public HealthPO Box 208034
60 College Street-LEPH 711

New Haven, CT 06520-8034

Curriculum Vitae