Departments & Organizations
Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology: B and T Cell Effector and Memory Cell Differentiation; Consequences of an Immune Response; Infectious Disease and Host-Pathogen Interaction; Regulating the Immune Response
Before joining Yale in 2010, Dr. Chen was a research scientist in Bristol-Myers Squibb and Professor in both Mayo Clinic and Johns Hopkins School of Medicine.
Dr. Chen studies cell surface proteins that stimulate or suppress lymphocyte functions (costimulation and coinhibition) and applies his laboratory finding to treat human diseases. In 1992, Dr. Chen did the first proof-of-concept study showing that manipulation of the B7-CD28 family molecules could be used for cancer immunotherapy by introducing B7-1 into tumor cells to enhance tumor immunity. This study inspired subsequent studies using antibodies targeting CTLA-4, one of the B7-CD28 family molecules, for the treatment of cancer. Dr. Chen co-discovered the PD-1/PD-L1 pathway and singularly established the PD-1/PD-L1 pathway as a target for cancer immunotherapy in 1999-2002. He initiated and help organized the first-in-man clinical trial of anti-PD-1 antibody for treating human cancer in 2006 and developed PD-L1 staining as a biomarker to predict treatment outcomes. Dr. Chen’s studies have revolutionized cancer treatment. His discoveries directly led to the development of anti-PD-1/PD-L1 antibody therapy against a broad spectrum of human cancers (first approved by the FDA in 2014).
Dr. Chen’s laboratory also discovered various costimulatory and coinhibitory pathways and their immunological functions and applications in human disease treatment. These pathways include 4-1BB, ICOS/B7-H2, B7-H3, B7-H4, B7-H5/CD28H, PD-1H, LIGHT/HVEM, TROY, B7-H2/CD28/CTLA-4 (human), and SALM5/HVEM. These discoveries led to the development of therapeutic agents including agonist anti-4-1BB antibody (cancer), anti-B7-H3 antibody (cancer) anti-B7-H4 antibody (cancer) and B7-H4Ig fusion protein (autoimmune diseases) which are currently in clinical trials. Dr. Chen has published more than 300 papers, reviews, book chapters and has edited two books.
Dr. Chen's work in the discovery of the PD-1/PD-L1 pathway in cancer therapy was cited as the #1 breakthrough of the years by Science magazine in 2013. He has received many awards and professional recognition, including the William B. Coley Award (2014), CAHON-Lifetime Achievement Award (2015), CAST-USA Excellence Award (2016) and the AAI-Steinman Award (2016).
Education & Training
|PhD||Drexel University (1989)|
|MS||Beijing Union Medical College, Beijing, China, Immunology (1986)|
|MD||Fujian Medical College (1982)|
|Postdoctoral fellow||University of Washington|
|Fellow||Beijing Union Medical College|
|Intern and Resident||Fujian Union Hospital|
Honors & Recognition
Shizhang Bei AwardThe Biophysical Society of China (2017)
CAST-USA Excellence AwardChinese Association for Science and Technology USA (2016)
AAI-Steinman AwardAmerican Association of Immunologists (2016)
CAHON-Lifetime Achievement AwardCAHON (2015)
William B. Coley AwardCancer Research Institute (2014)
Inaugural United Technologies Corporation Endowed Chair ProfessorYale University (2013)
Honorary Master of ArtsYale University (2012)