Erol Fikrig, MD

Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis; Investigator, Howard Hughes Medical Institute; Section Chief, Infectious Diseases

Departments & Organizations


Internal Medicine: Infectious Diseases

Microbial Pathogenesis

Molecular Virology: Virology laboratories

Office of Student Research

School of Public Health: Parasitology Program

Skin Diseases Research Center, Yale

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology: Computational Immunology; Infectious Disease and Host-Pathogen Interaction | Microbiology: Bacteria; Viruses

Yale Medical Group


My laboratory investigates vector-borne diseases. Studies are directed toward understanding Lyme disease, Human granulocytic ehrlichiosis, and West Nile virus. Efforts on Lyme disease include exploring immunity to Borrelia burgdorferi, selective B. burgdorferi gene expression in vivo, and the immunobiology of Lyme arthritis. Human granulocytic ehrlichiosis is caused by a newly described pathogen, transmitted by Ixodes scapularis ticks, that persists within neutrophils. We are investigating the molecular strategies that this pathogen uses to survive in polymorphonuclear leukocytes. West Nile virus can cause fatal encephalitis, and we seek to understand the pathogenesis of this emerging disease. Finally, we are also developing molecular approaches to prevent ticks from feeding on a mammalian host, thereby interfering with pathogen transmission.

Education & Training

MD Cornell University (1985)
BA Cornell University (1981)
Resident Vanderbilt University Hospital
Fellow Yale University School of Medicine

International Activity

  • West-Nile Virus Protein Canada (2010)

    Yale and McGill University scientists have identified a protein that is critical in fighting mosquito-borne West Nile Virus in mice. This finding could have therapeutic implications for controlling the potentially deadly virus in humans. The study appears in the Advance Online Publication of Nature...

  • Pathogenesis of Lyme Disease Netherlands; Netherlands (2007)

    The goal of this project is to determine how specific components of the Lyme disease agent, Borrelia burgdorferi, and its arthropod vector, Ixodes ticks, contribute to the pathogenesis of Lyme disease in Europe.

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