Research Areas

Cell Cycle and Signal Transduction

Control of the cell cycle, cell signaling, Protein kinases, Chemical genetics, Proteomics.

DNA Dynamics

Replication, Recombination, Repair, Transposition, Chromosome structure, Functional genomics.

Drug Design, Discovery and Mechanism

Membrane Biology and Motion

Transmembrane signalling, Vesicle transport, Growth factor receptors, Membrane channels, Cytoskeleton.


Neurotransmission in C. elegans, mice and tissue culture systems.

Protein Folding, Dynamics and Degradation

Chaperone structure and function, protein design, the proteasome, amyloid fibril formation, ubiquitin-mediated proteolysis.

RNA Catalysis and Ribonucleoprotein Machines

Self-splicing introns and spliceosomes, RNA stability and qulity control, RNA editing and modification, Ribosome structure and function, tRNA recognition and biosynthesis, HIV reverse transcriptase.

Transcriptional Regulation

RNA polymerase, Transcription factors, Lymphocyte activation.

Virology, Infection and Immunity

The following are faculty who are addressing problems using crystallography, NMR, mass spectrometry, cryo-electron microscopy, or computational methods.