Biochemistry, Biophysics, and Structural Biology Faculty
Murat Acar
Assistant Professor of Molecular, Cellular, and Developmental Biology
Research Interests:Systems biology, synthetic biology, gene regulatory networks, noise in gene expression, aging, evolution of gene networks.
Karen Anderson
Professor of Pharmacology and of Molecular Biophysics and Biochemistry
Co-Director Therapeutics/Chemotherapy Program
Research Interests:Enzyme function; Anti-viral agents
Susan Baserga
Professor of Molecular Biophysics and Biochemistry, of Genetics and of Therapeutic Radiology
Research Interests:Ribosome biogenesis; rRNA processing; U3 RNP structure and function; RNA helicases; Polymerase I transcription and processing
Richard Baxter
Assistant Professor of Chemistry and of Molecular Biophysics and Biochemistry
George Beardsley
Professor of Pediatrics
Research Interests:Biology of Osteosarcoma; Molecular enzymology of purine biosynthesis indicators for osteosarcoma; Molecular Pharmacology of anticancer and antiviral drugs which alter DNA structure; Biochemical Pharmacology of antifolate drugs; Development of novel antifolates
Joerg Bewersdorf
Assistant Professor of Cell Biology and of Biomedical Engineering
Research Interests:Super-resolution fluorescence microscopy
Thomas Biederer
Associate Professor of Molecular Biophysics and Biochemistry
Research Interests:Biochemistry of membrane proteins; molecular and cellular neuroscience; synapse formation
Titus Boggon
Associate Professor of Pharmacology
Research Interests:Structural biology of signal transduction
Demetrios Braddock
Associate Professor of Pathology
Research Interests:Structural biology; Hematopathology; Genitourinary Pathology
Ronald Breaker
Henry Ford II Professor of Molecular, Cellular, and Developmental Biology
Investigator, Howard Hughes Medical Institute
Research Interests:non-coding RNA; riboswitches; ribozymes; catalytic DNA; RNA's role in evolution
Gary Brudvig
Eugene Higgins Professor of Chemistry and Professor of Molecular Biophysics and Biochemistry
Research Interests:photosystem II; EPR spectroscopy; metalloproteins; artificial photosynthesis
David Calderwood
Associate Professor of Pharmacology and of Cell Biology
Research Interests:Integrin; Cell adhesion; Cell migration; Cytoskeleton; Structural biology
Topher Carroll
Assistant Professor of Cell Biology
Research Interests:Epigenetics; Chromosomes; Chromatin; Gene expression; Nuclear Organization; Nuclear Membrane;
Yung-Chi Cheng
Henry Bronson Professor of Pharmacology
Chairman, Consortium for the Globalization of Chinese Medicine (CGCM)
Research Interests:Cancer; Viral chemotherapy; Chinese herbs; Chinese medicine
Craig Crews
Lewis B. Cullman Professor of Molecular, Cellular, and Developmental Biology and Professor of Chemistry and of Pharmacology
Executive Director, Yale Molecular Discovery Center
Research Interests:Limb regeneration; wound epidermis; blastema; natural product mode of action studies; angiogenesis; Wnt signaling; protein turnover; protein kinase regulation
Enrique De La Cruz
Professor of Molecular Biophysics and Biochemistry
Research Interests:Cytoskeleton; RNA helicases; Kinetics; Thermodynamics; Polymer Mechanics; Processivity
Daniel DiMaio
Waldemar Von Zedtwitz Professor of Genetics and Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology
Scientific Director, Yale Cancer Center
Deputy Director, Yale Cancer Center
Research Interests:Molecular Biology of Tumor Viruses; Mechanisms of Viral Carcinogenesis; Molecular Basis of Cell Growth Regulation and Senescence; Manipulating Cells and Viruses with Artificial Transmembrane Proteins; Oncogenes; Senescence ; Signal Transduction; Trans-membrane Proteins; Tumor Suppressor Genes; Virology; Virus
Barbara Ehrlich
Professor of Pharmacology and of Cellular and Molecular Physiology
Research Interests:Intracellular calcium regulation
Jonathan Ellman
Professor of Chemistry
Pharmacology
Research Interests:proteases, phosphatases, inhibitors, C-H functionalization, asymmetric amine synthesis
Donald Engelman
Eugene Higgins Professor of Molecular Biophysics and Biochemistry
Research Interests:Helix Interactions; Lipid Bilayers; Membranes; Physical Biochemistry; Protein Folding; Proteins
V. Eswarakumar
Assistant Professor of Orthopaedics and Rehabilitation and of Pharmacology
Research Interests:Fibroblast Growth Factor Receptors (FGFRs)
Shawn Ferguson
Assistant Professor of Cell Biology
Research Interests:lysosomes; membrane traffic; energy homeostasis; nutrient homeostasis; transcription factor; signaling; neurodegeneration; neuronal ceroid lipofuscinosis; genetics
Alan Garen
Professor of Molecular Biophysics and Biochemistry
Research Interests:Development; Genetics; Medical Sciences; Molecular Biology
Mark Gerstein
Albert L. Williams Professor of Biomedical Informatics
Co-Director, Yale Computational biology and Bioinformatics Program
Research Interests:Biochemistry; Bioinformatics; Biophysics; Computational Biology; DNA; Genomics; Molecular Simulation; Proteins; Sequence Alignment; Structural Biology
Antonio Giraldez
Associate Professor of Genetics
Member of the Yale Cancer Center
Member of the Stem Cell Center
Director of Graduate Studies
Research Interests:Non-coding RNAs, Post-transcriptional regulation; microRNAs; Developmental Biology; Gene regulatory networks; Systems Biology; Zebrafish
Ya Ha
Associate Professor of Pharmacology
Research Interests:Membrane protein; X-ray crystallography; Enzyme mechanism
Mark Hochstrasser
Eugene Higgins Professor of Molecular Biophysics and Biochemistry and Professor of Molecular, Cellular, and Developmental Biology
Research Interests:Adenosinetriphosphatase; Cell Growth Regulation; Chemical Cleavage; Chemical Conjugate; Chimeric Protein; Enzyme Activity; Enzyme Complex; Enzyme Mechanism; Enzyme Structure; Fungal Genetics; Gene Deletion Mutation; Immunoelectron Microscopy; Isozyme; Mass Spectrometry; Mutant; Proteasome; Protein Degradation; Protein Purification; Proteinase; Protooncogene; Saccharomyces Cerevisiae; Transcription Factor; Ubiquitin
Michael Hodsdon
Associate Professor of Laboratory Medicine and of Pharmacology
Assoc. Director, Clinical Chemistry Laboratory
Research Interests:Biochemistry; Biophysics; Breast Cancer; Clinical Chemistry; Drug Metabolism; Health and Medicine; Laboratory Practice or Procedure; Nuclear Magnetic Resonance; Pathobiology; Pharmacology; Spectroscopy; Structural Biology; Toxicology
Arthur Horwich
Sterling Professor of Genetics and Professor of Pediatrics
and Investigator HHMI
Research Interests:Chaperones in protein folding; ALS (Lou Gehrig's Disease)
Farren Isaacs
Assistant Professor of Molecular, Cellular, and Developmental Biology
Research Interests:Synthetic Biology; Systems Biology; Genomics; Biotechnology
Megan King
Assistant Professor of Cell Biology
Research Interests:microtubules; nucleus; nuclear envelope; DNA repair; cellular mechanics; telomere biology
Michael Koelle
Associate Professor of Molecular Biophysics and Biochemistry
Research Interests:C. Elegans; G Protein; Neurotransmission; RGS Protein; Serotonin; Molecular Genetics; Neurobiology; Neurotransmitters; Proteins and Macromolecules; Receptors
Anthony Koleske
Professor of Molecular Biophysics and Biochemistry and of Neurobiology
Research Interests:Neuronal morphogenesis and degeneration; stress; schizophrenia; cell migration; cancer; metastasis; adhesion receptors
William Konigsberg
Professor of Molecular Biophysics and Biochemistry
Research Interests:Blood Coagulation; DNA Replication; Genetics; Proteins and Macromolecules
Richard Lifton
Sterling Professor of Genetics and Professor of Medicine (Nephrology)
Chair, Department of Genetics
Investigator, Howard Hughes Medical Institute
Research Interests:Molecular genetics of common human diseases
Chenxiang Lin
Assistant Professor of Cell Biology
Research Interests:Engineering DNA-nanostructure-based molecular tools for biological study
Haifan Lin
Professor of Cell Biology and of Genetics
Director, Yale Stem Cell Center
Research Interests:RNA-mediated epigenetic programming and post-transcriptional regulation of stem cells
Paul Lizardi
Professor of Pathology
Research Interests:Cancer Genetics/Epigenetics; Cancer biology; Dynamics of abnormal chromatin states in neoplasia and metastasis; DNA amplification technology (MDA, RCA); DNA microarray technology for epigenetic analysis, array-CGH; Proteomics analysis of cancer tissues
Elias Lolis
Professor of Pharmacology
Director of Graduate Studies
Research Interests:Cancer; Inflammation; Infectious disease; macromolecular X-ray crystallography; Signaling pathways; Drug design; High throughput screening (HTPS)
J Patrick Loria
Professor of Chemistry and of Molecular Biophysics and Biochemistry
Research Interests:Protein Folding
Jun Lu
Assistant Professor of Genetics
Research Interests:Non-coding RNAs in blood stem cell differentiation and malignancies; MicroRNA-mediated control of embryonic stem cell fates; MicroRNA mechanisms
Patrick Lusk
Assistant Professor of Cell Biology
Research Interests:nuclear pore complex; nuclear periphery; membrane proteins; chromatin structure
Malaiyalam Mariappan
Assistant Professor of Cell Biology
Research Interests:Membrane protein homeostasis; Membrane protein targeting and insertion; Membrane protein assembly; Misfolded membrane protein degradation; Biochemical reconstitution
I George Miller, Jr
John F. Enders Professor of Pediatrics (Infectious Disease) and Professor of Epidemiology (Microbial Diseases) and of Molecular Biophysics and Biochemistry
Section Chief, Pediatric Infectious Diseases
Research Interests:Epstein-Barr Virus (EBV); Kaposi's Sarcoma-Associated Herpesvirus (KSHV); Tumor virology
Andrew Miranker
Professor of Molecular Biophysics and Biochemistry
Research Interests:Conformational changes in proteins which give rise to a special class of protein complex known as amyloid fibrils
Yorgo Modis
Associate Professor of Molecular Biophysics and Biochemistry
Research Interests:Bacterial Infections; Biochemistry; Biophysics; Disease Resistance; Immune System; Immune System Disorders; Immunology; Infectious Diseases or Agents; Inflammatory Bowel Disease; Natural Processes Health Safety Medical; Pathogenesis; Receptors; Structural Biology; Structure or Function (Health or Safety or Medical); Vaccine
Nancy Moran
William H. Fleming, M.D. Professor of Ecology and Evolutionary Biology
Research Interests:Symbiosis; Genomics; Evolutionary Biology; metagenomics; metabolism
Elijah Paintsil
Assistant Professor of Pediatrics (Infectious Disease) and of Pharmacology
Research Interests:HIV translational research; cellular pharmacology of HIV-RT inhibitors in relation to clinical toxicities; Fitness and evolution of HIV drug resistant mutants; Molecular epidemiology and dynamics of HIV/HCV transmission
Thomas Pollard
Sterling Professor of Molecular, Cellular, and Developmental Biology and Professor of Cell Biology and of Molecular Biophysics and Biochemistry
Dean of the Graduate School of Arts and Sciences
Research Interests:Cytokinesis; cellular motility; role of actin filaments and myosin motors
Anna Marie Pyle
William Edward Gilbert Professor of Molecular, Cellular, and Developmental Biology and Professor of Chemistry
Director, Division of Biological Sciences
Research Interests:Structure and function of catalytic RNA; RNA helicase mechanisms; Computational analysis of RNA structure
Lynne Regan
Professor of Molecular Biophysics and Biochemistry and of Chemistry
Research Interests:Mental retardation; protein-protein interactions; Fragile X Mental Retardation Protein (FMRP); protein-based nanomaterials
Karin Reinisch
Associate Professor of Cell Biology
Elizabeth Rhoades
Associate Professor of Molecular Biophysics and Biochemistry and of Physics
Research Interests:Protein-Protein Interactions; Disordered Proteins; Protein Aggregation; Protein Folding; Fluorescence Spectroscopy
James Rothman
Fergus F. Wallace Professor of Cell Biology and Professor of Chemistry and Residential College Associate Fellow in Faculty of Arts and Sciences
Chairman, Department of Cell Biology
Director, Nanobiology Institute
Research Interests:Elucidating the underlying mechanisms of vesicular transport within cells and the secretion of hormones and neurotransmitters
Gary Rudnick
Professor of Pharmacology
Research Interests:Neurotransmitter recycling; Mechanism of membrane transport
David Schatz
Professor of Immunobiology
Professor of Molecular Biophysics and Biochemistry
Research Interests:Biochemical mechanism and developmental regulation of V(D)J recombination and somatic hypermutation; lymphocyte development; mechanisms of DNA repair; function of the RAG1 and RAG2 proteins; mechanisms of lymphomagenesis
Joseph Schlessinger
William H. Prusoff Professor of Pharmacology
Chair, Pharmacology
Director, Cancer Biology Institute
Research Interests:Growth factor receptors; Intracellular signaling pathways;protein kinases; phosphorylation; SH2, SH3 and other protein modules involved in signal transduction; drug discovery
Christian Schlieker
Assistant Professor of Molecular Biophysics and Biochemistry
Research Interests:Protein folding; ubiquitin; Protein quality control and its relation to viral pathogenesis
Frederick Sigworth
Professor of Cellular and Molecular Physiology and of Biomedical Engineering
Research Interests:Cell Physiology; Electron Microscopy; Electrophysiology; Ion Channel; Mathematical Model; Patch Clamp; Potassium Channel; Protein Structure; Sodium Channel; Voltage Gated Channel; Xenopus Oocyte
Matthew Simon
Assistant Professor of Molecular Biophysics and Biochemistry and Residential College Associate Fellow in Faculty of Arts and Sciences
Assistant Professor of Molecular Biophysics and Biochemistry (starting next year)
Research Interests:Chemical biology; Large non-coding RNAs; Epigenetic regulation; Histone modifications
Chuck Sindelar
Assistant Professor of Molecular Biophysics and Biochemistry
Satinder Singh
Assistant Professor of Cellular and Molecular Physiology
Research Interests:Chemical neurotransmission; Neuropsychiatric disease; Epilepsy; Neuropharmacology; Biogenic amine; Gamma-aminobutyric acid; Neurotransmitter transporter; Antidepressant; Structural neurobiology; X-ray crystallography; Transporter kinetics
Dieter Soll
Sterling Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry
Research Interests:Aminoacyl-tRNA Synthesis; Functional Genomics; Life Science Biological; Mechanism of Translation
Mark Solomon
Professor of Molecular Biophysics and Biochemistry
Research Interests:Cell cycle; Ubiquitin-mediated proteolysis; Anaphase-promoting Complex
Joan Steitz
Sterling Professor of Molecular Biophysics and Biochemistry
Investigator, Howard Hughes Medical Institute
Research Interests:Autoantibodies; Gene Expression; RNA; RNA Processing; SnRNPs; Viral Transformation
Thomas Steitz
Sterling Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry
Investigator, Howard Hughes Medical Institute
Research Interests:Protein Structure; Proteins and Macromolecules; Protein Nucleic Acid Complexes; X-ray Crystallography
Scott Strobel
Henry Ford II Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry
Howard Hughes Medical Institute Professor
Henry Ford II Professor
Research Interests:Antibiotics; Nucleic Acid Bioorganic Chemistry; Ribosome; Ribozyme; RNA Catalysis; RNA-Protein Interaction; Translation; Riboswitches, Biofuels; Endophytes; Natural Product Discovery
William Summers
Professor of Therapeutic Radiology, in the History of Medicine and of Molecular Biophysics and Biochemistry
Lecturer in History
Research Interests:History of molecular biology; Development of target theory; History of Manchurian Plague, 1910-1911
Patrick Sung
Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology
Research Interests:Repair of DNA double-strand breaks; repair by homologous recombination; repair by DNA end-joining
Derek Toomre
Associate Professor of Cell Biology
Research Interests:Cell Biology; Exocytosis; Endocytosis; Membrane Traffic; Tethering; Microscopy; Live Cell Imaging; TIRFM; Single molecule
Benjamin Turk
Associate Professor of Pharmacology
Research Interests:Cell signaling; Protein kinases; Chemical biology; Proteomics; Metalloproteases; Protein engineering
Tobias Walther
Associate Professor of Cell Biology
Research Interests:Organelle homeostasis; Plasma membrane organization; Lipid metabolism; Lipid Droplets; Eisosomes; Sphingolipid metabolism; Systematic genetics; RNAi screening; Mass-spectrometry based proteomics
Corey Wilson
Assistant Professor of Chemical Engineering, of Biomedical Engineering and of Molecular Biophysics and Biochemistry
Sandra Wolin
Professor of Cell Biology and of Molecular Biophysics and Biochemistry
Vice Chair, Department of Cell Biology
Research Interests:RNA quality control; noncoding RNAs; RNA damage; autoimmune disease
Yong Xiong
Associate Professor of Molecular Biophysics and Biochemistry
Research Interests:Innate immune systems; HIV; fatty acid synthase (FAS); polyketide synthase (PKS); Viral vectors
Elsa Yan
Associate Professor of Chemistry
Research Interests:GPCRs, membrane proteins, biophysical spectroscopy, surface science, protein-membrane interactions
Jie Yao
Assistant Professor of Cell Biology
Research Interests:Transcription regulation; chromatin; nuclear periphery; nuclear compartmentalization; protein dynamics; cellular biophysics and imaging
Yongli Zhang
Assistant Professor of Cell Biology
Research Interests:Single-molecule biophysics and biochemistry; optical tweezers; ATP-dependent chromatin remodeling; SNAREs; membrane fusion; dynamin; membrane fission
