Publications

Dell'Anno MT, Strittmatter SM: Rewiring the spinal cord: Direct and indirect strategies. Neurosci Lett. 2017 Jun 23; 2016 Dec 19. PMID: 28007647

Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM, Alzheimer’s Disease Neuroimaging Initiative.: Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017 May; 2017 Jan 9. PMID: 28070672

Smith LM, Strittmatter SM: Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity. Cold Spring Harb Perspect Med. 2017 May 1; 2017 May 1. PMID: 27940601

Gayle S, Landrette S, Beeharry N, Conrad C, Hernandez M, Beckett P, Ferguson SM, Mandelkern T, Zheng M, Xu T, Rothberg J, Lichenstein H: Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma. Blood. 2017 Mar 30; 2017 Jan 19. PMID: 28104689

Andrade EC, Musante V, Horiuchi A, Matsuzaki H, Brody AH, Wu T, Greengard P, Taylor JR, Nairn AC: ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase). J Neurosci. 2017 Mar 8; 2017 Feb 6. PMID: 28167675

Barthas F, Kwan AC: Secondary Motor Cortex: Where 'Sensory' Meets 'Motor' in the Rodent Frontal Cortex. Trends Neurosci. 2017 Mar; 2016 Dec 22. PMID: 28012708

Salazar SV, Strittmatter SM: Cellular prion protein as a receptor for amyloid-β oligomers in Alzheimer's disease. Biochem Biophys Res Commun. 2017 Feb 19; 2016 Sep 14. PMID: 27639648

Nishi A, Matamales M, Musante V, Valjent E, Kuroiwa M, Kitahara Y, Rebholz H, Greengard P, Girault JA, Nairn AC: Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution. J Biol Chem. 2017 Jan 27; 2016 Dec 20. PMID: 27998980

Wang X, Sekine Y, Byrne AB, Cafferty WB, Hammarlund M, Strittmatter SM: Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury. eNeuro. 2016 Nov-Dec; 2016 Dec 26. PMID: 28032120

Amick J, Roczniak-Ferguson A, Ferguson SM: C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling. Mol Biol Cell. 2016 Oct 15; 2016 Aug 24. PMID: 27559131

Bhagat SM, Butler SS, Taylor JR, McEwen BS, Strittmatter SM: Erasure of fear memories is prevented by Nogo Receptor 1 in adulthood. Mol Psychiatry. 2016 Sep; 2015 Dec 1. PMID: 26619810

Siniscalchi MJ, Phoumthipphavong V, Ali F, Lozano M, Kwan AC: Fast and slow transitions in frontal ensemble activity during flexible sensorimotor behavior. Nat Neurosci. 2016 Sep; 2016 Jul 11. PMID: 27399844

Tisher A, Salardini A: A case report of a woman with young onset cognitive impairment associated with hereditary spastic paraplegia due to a mutation in the SPAST gene. J Neurol Sci. 2016 Aug 15; 2016 May 31. PMID: 27423575

Haas LT, Strittmatter SM: Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease. J Biol Chem. 2016 Aug 12; 2016 Jun 20. PMID: 27325698

Gray MA, Choy CH, Dayam RM, Ospina-Escobar E, Somerville A, Xiao X, Ferguson SM, Botelho RJ: Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB. Curr Biol. 2016 Aug 8; 2016 Jul 7. PMID: 27397893

Ikram MQ, Sajjad FH, Salardini A: The head that wears the crown: Henry VIII and traumatic brain injury. J Clin Neurosci. 2016 Jun; 2016 Feb 5. PMID: 26857293

Han L, Gill TM, Jones BL, Allore HG: Cognitive Aging Trajectories and Burdens of Disability, Hospitalization and Nursing Home Admission Among Community-living Older Persons. J Gerontol A Biol Sci Med Sci. 2016 Jun; 2015 Oct 28. PMID: 26511011

Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J: TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 2016 May 18. PMID: 27196974

Phoumthipphavong V, Barthas F, Hassett S, Kwan AC: Longitudinal Effects of Ketamine on Dendritic Architecture In Vivo in the Mouse Medial Frontal Cortex. eNeuro. 2016 Mar-Apr; 2016 Apr 4. PMID: 27066532

Gowrishankar S, Ferguson SM: Lysosomes relax in the cellular suburbs. J Cell Biol. 2016 Mar 14. PMID: 26975848

Hillmer AT, Zheng MQ, Li S, Scheunemann M, Lin SF, Holden D, Labaree D, Ropchan J, Teodoro R, Deuther-Conrad W, Carson RE, Brust P, Huang Y: PET imaging evaluation of [(18)F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates. Eur J Nucl Med Mol Imaging. 2016 Mar; 2015 Oct 12. PMID: 26455500

Buurman BM, Han L, Murphy TE, Gahbauer EA, Leo-Summers L, Allore HG, Gill TM: Trajectories of Disability Among Older Persons Before and After a Hospitalization Leading to a Skilled Nursing Facility Admission. J Am Med Dir Assoc. 2016 Mar 1; 2015 Nov 24. PMID: 26620073

Haas LT, Salazar SV, Kostylev MA, Um JW, Kaufman AC, Strittmatter SM: Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease. Brain. 2016 Feb; 2015 Dec 14. PMID: 26667279

Yuan P, Grutzendler J: Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. J Neurosci. 2016 Jan 13. PMID: 26758850

Allore H: Special Issue: Methods for Estimating Treatment Effects for Persons with Multiple Chronic Conditions. Int J Stat Med Res. 2016. PMID: 27559427

Han L, Pisani MA, Araujo KL, Allore HG: Use of Self-Matching to Control for Stable Patient Characteristics While Addressing Time-Varying Confounding on Treatment Effect: A Case Study of Older Intensive Care Patients. Int J Stat Med Res. 2016; 2016 Jan 8. PMID: 27123153

Chahine LM, Weintraub D, Hawkins KA, Siderowf A, Eberly S, Oakes D, Seibyl J, Stern MB, Marek K, Jennings D, PARS Investigators.: Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings. Mov Disord. 2016 Jan; 2015 Aug 21. PMID: 26293177

Yamagata Y, Nairn AC: Contrasting features of ERK1/2 activity and synapsin I phosphorylation at the ERK1/2-dependent site in the rat brain in status epilepticus induced by kainic acid in vivo. Brain Res. 2015 Nov 2; 2015 Aug 28. PMID: 26320550

Coric V, Salloway S, van Dyck CH, Dubois B, Andreasen N, Brody M, Curtis C, Soininen H, Thein S, Shiovitz T, Pilcher G, Ferris S, Colby S, Kerselaers W, Dockens R, Soares H, Kaplita S, Luo F, Pachai C, Bracoud L, Mintun M, Grill JD, Marek K, Seibyl J, Cedarbaum JM, Albright C, Feldman HH, Berman RM: Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial. JAMA Neurol. 2015 Nov. PMID: 26414022

Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer JB, Rissman RA, Raman R, Aisen PS, Alzheimer's Disease Cooperative Study.: A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015 Oct 20; 2015 Sep 11. PMID: 26362286

Ferguson SM: MEDICINE. Membrane traffic en route to cancer. Science. 2015 Oct 9. PMID: 26450197

Sandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O'Connor KC, Huang Y, Carson RE, Hannestad J, Cosgrove KP: Imaging robust microglial activation after lipopolysaccharide administration in humans with PET. Proc Natl Acad Sci U S A. 2015 Oct 6; 2015 Sep 18. PMID: 26385967

Tinetti ME, McAvay G, Trentalange M, Cohen AB, Allore HG: Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study. BMJ. 2015 Oct 2; 2015 Oct 2. PMID: 26432468

Keung B, Huttner A: A 15-year-old girl with a rapidly progressing tumor-like lesion. Neuropathology. 2015 Oct; 2015 May 25. PMID: 26011248

Allore HG, Zhan Y, Tinetti M, Trentalange M, McAvay G: Longitudinal average attributable fraction as a method for studying time-varying conditions and treatments on recurrent self-rated health: the case of medications in older adults with multiple chronic conditions. Ann Epidemiol. 2015 Sep; 2015 May 8. PMID: 26033374

Park E, Sullivan JM, Planeta B, Gallezot JD, Lim K, Lin SF, Ropchan J, McCarthy TJ, Ding YS, Morris ED, Williams WA, Huang Y, Carson RE: Test-retest reproducibility of the metabotropic glutamate receptor 5 ligand [¹⁸F]FPEB with bolus plus constant infusion in humans. Eur J Nucl Med Mol Imaging. 2015 Sep; 2015 Jun 5. PMID: 26044120

Vaughan L, Hogan PE, Rapp SR, Dugan E, Marottoli RA, Snively BM, Shumaker SA, Sink KM: Driving with Mild Cognitive Impairment or Dementia: Cognitive Test Performance and Proxy Report of Daily Life Function in Older Women. J Am Geriatr Soc. 2015 Sep; 2015 Sep 4. PMID: 26338449

Ceglia I, Reitz C, Gresack J, Ahn JH, Bustos V, Bleck M, Zhang X, Martin G, Simon SM, Nairn AC, Greengard P, Kim Y: APP intracellular domain-WAVE1 pathway reduces amyloid-β production. Nat Med. 2015 Sep; 2015 Aug 17. PMID: 26280122

Ferguson SM: Beyond indigestion: emerging roles for lysosome-based signaling in human disease. Curr Opin Cell Biol. 2015 Aug; 2015 May 15. PMID: 25950843

Sun J, Kil C, Stankewich MC, Yao Z, Li J, Vortmeyer AO: A 10-minute prototype assay for tissue degradation monitoring in clinical specimens. Exp Mol Pathol. 2015 Aug; 2015 May 30. PMID: 26033311

Spellman DS, Wildsmith KR, Honigberg LA, Tuefferd M, Baker D, Raghavan N, Nairn AC, Croteau P, Schirm M, Allard R, Lamontagne J, Chelsky D, Hoffmann S, Potter WZ, Alzheimer's Disease Neuroimaging Initiative., Foundation for NIH (FNIH) Biomarkers Consortium CSF Proteomics Project Team.: Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF. Proteomics Clin Appl. 2015 Aug; 2015 Apr 24. PMID: 25676562

Zou Y, Stagi M, Wang X, Yigitkanli K, Siegel CS, Nakatsu F, Cafferty WB, Strittmatter SM: Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury. J Neurosci. 2015 Jul 22. PMID: 26203138

Gowrishankar S, Yuan P, Wu Y, Schrag M, Paradise S, Grutzendler J, De Camilli P, Ferguson SM: Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques. Proc Natl Acad Sci U S A. 2015 Jul 14; 2015 Jun 29. PMID: 26124111

Kostylev MA, Kaufman AC, Nygaard HB, Patel P, Haas LT, Gunther EC, Vortmeyer A, Strittmatter SM: Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models. J Biol Chem. 2015 Jul 10; 2015 May 27. PMID: 26018073

Xu X, Liang J, Bennett JM, Botoseneanu A, Allore HG: Socioeconomic stratification and multidimensional health trajectories: evidence of convergence in later old age. J Gerontol B Psychol Sci Soc Sci. 2015 Jul; 2014 Aug 26. PMID: 25161216

Hill RA, Tong L, Yuan P, Murikinati S, Gupta S, Grutzendler J: Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes. Neuron. 2015 Jul 1; 2015 Jun 25. PMID: 26119027

Kaufman AC, Salazar SV, Haas LT, Yang J, Kostylev MA, Jeng AT, Robinson SA, Gunther EC, van Dyck CH, Nygaard HB, Strittmatter SM: Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann Neurol. 2015 Jun; 2015 Mar 21. PMID: 25707991

Park E, Gallezot JD, Delgadillo A, Liu S, Planeta B, Lin SF, O'Connor KC, Lim K, Lee JY, Chastre A, Chen MK, Seneca N, Leppert D, Huang Y, Carson RE, Pelletier D: (11)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas. Eur J Nucl Med Mol Imaging. 2015 Jun; 2015 Apr 2. PMID: 25833352

Weintraub D, Simuni T, Caspell-Garcia C, Coffey C, Lasch S, Siderowf A, Aarsland D, Barone P, Burn D, Chahine LM, Eberling J, Espay AJ, Foster ED, Leverenz JB, Litvan I, Richard I, Troyer MD, Hawkins KA, Parkinson's Progression Markers Initiative.: Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease. Mov Disord. 2015 Jun; 2015 Mar 4. PMID: 25737166

Bois F, Gallezot JD, Zheng MQ, Lin SF, Esterlis I, Cosgrove KP, Carson RE, Huang Y: Evaluation of [(18)F]-(-)-norchlorofluorohomoepibatidine ([(18)F]-(-)-NCFHEB) as a PET radioligand to image the nicotinic acetylcholine receptors in non-human primates. Nucl Med Biol. 2015 Jun; 2014 Aug 8. PMID: 25858513

Gill TM, Gahbauer EA, Han L, Allore HG: The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people. BMJ. 2015 May 20; 2015 May 20. PMID: 25995357

Nygaard HB, Kaufman AC, Sekine-Konno T, Huh LL, Going H, Feldman SJ, Kostylev MA, Strittmatter SM: Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model. Alzheimers Res Ther. 2015; 2015 May 5. PMID: 25945128

Nygaard HB, Wagner AF, Bowen GS, Good SP, MacAvoy MG, Strittmatter KA, Kaufman AC, Rosenberg BJ, Sekine-Konno T, Varma P, Chen K, Koleske AJ, Reiman EM, Strittmatter SM, van Dyck CH: A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease. Alzheimers Res Ther. 2015; 2015 Apr 14. PMID: 25874001

Willinger T, Staron M, Ferguson SM, De Camilli P, Flavell RA: Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes. Proc Natl Acad Sci U S A. 2015 Apr 7; 2015 Mar 23. PMID: 25831514

Colangelo CM, Ivosev G, Chung L, Abbott T, Shifman M, Sakaue F, Cox D, Kitchen RR, Burton L, Tate SA, Gulcicek E, Bonner R, Rinehart J, Nairn AC, Williams KR: Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins. Proteomics. 2015 Apr; 2015 Feb 12. PMID: 25476245

Wang X, Lin J, Arzeno A, Choi JY, Boccio J, Frieden E, Bhargava A, Maynard G, Tsai JC, Strittmatter SM: Intravitreal delivery of human NgR-Fc decoy protein regenerates axons after optic nerve crush and protects ganglion cells in glaucoma models. Invest Ophthalmol Vis Sci. 2015 Feb 5; 2015 Feb 5. PMID: 25655801

Colangelo CM, Shifman M, Cheung KH, Stone KL, Carriero NJ, Gulcicek EE, Lam TT, Wu T, Bjornson RD, Bruce C, Nairn AC, Rinehart J, Miller PL, Williams KR: YPED: an integrated bioinformatics suite and database for mass spectrometry-based proteomics research. Genomics Proteomics Bioinformatics. 2015 Feb; 2015 Feb 21. PMID: 25712262

Condello C, Yuan P, Schain A, Grutzendler J: Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nat Commun. 2015 Jan 29; 2015 Jan 29. PMID: 25630253

Kurup PK, Xu J, Videira RA, Ononenyi C, Baltazar G, Lombroso PJ, Nairn AC: STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease. Proc Natl Acad Sci U S A. 2015 Jan 27; 2015 Jan 12. PMID: 25583483